10MG diazepam perp ill 10 pills per strip. European script

Product Overview

Generic Name: Diazepam

Brand Names: Valium® (Roche), Diastat® (rectal gel), Valtoco® (nasal spray), various generics

DEA Schedule: C-IV (Schedule IV Controlled Substance) [citation:3][citation:6]

Drug Class: Benzodiazepine, Benzodiazepine Anticonvulsant [citation:3]

Pregnancy Category: D – Positive evidence of human fetal risk [citation:3][citation:6]

Diazepam is a long-acting benzodiazepine with anxiolytic, anticonvulsant, sedative, muscle relaxant, and amnestic properties. It was first synthesized by Roche and approved by the FDA in 1963, becoming one of the most prescribed medications in the world during the 1970s.

Common 10mg Tablet Imprints & Manufacturers

The following list includes **genuine, FDA-approved** 10mg diazepam tablets based on official registrations. Always verify using the NDC (National Drug Code) or consult a pharmacist.

Imprint/Score	Manufacturer	Color/Shape	NDC (Last 4-5 digits)
ROCHE / ROCHE / VALIUM 10 [citation:6]	Roche Laboratories (Brand)	Blue / Round / 9mm	00140-0006
3927 / TEVA [citation:2]	Teva Pharmaceuticals USA	Blue / Round / 8mm	0172-3927
Z 3927 10 [citation:5][citation:9]	Ivax Pharmaceuticals (Teva)	Blue / Round / 8mm	00172-3927
D 10 [citation:3]	Aurobindo Pharma	Blue / Round	59651-0654
C | DC (with score line) [citation:1]	Actavis UK (Historical)	Blue / Round / Beveled edge	Discontinued in UK

Indications and Usage

Diazepam is indicated for [citation:3]:

• Anxiety Disorders: Management of generalized anxiety disorder (GAD)
• Acute Alcohol Withdrawal: Relief of agitation, tremor, and impending delirium tremens
• Muscle Spasms: Adjunct for relief of skeletal muscle spasm due to local trauma or cerebral palsy
• Seizure Disorders: Adjunct in the management of certain seizure disorders
• Pre-procedural Sedation: Premedication for endoscopy or radiology procedures

Mechanism of Action

Diazepam acts as a positive allosteric modulator of the GABA-A receptor. By binding to specific benzodiazepine receptors, it enhances the affinity of gamma-aminobutyric acid (GABA) for its receptor, increasing chloride channel opening frequency. This leads to hyperpolarization of neurons and a reduction in central nervous system excitability, producing anxiolytic, sedative, muscle relaxant, and anticonvulsant effects.

Pharmacokinetics

Parameter	Information
Onset of action (oral)	30-60 minutes
Peak plasma concentration	1-1.5 hours
Duration of action (single dose)	6-12 hours (primary effects)
Elimination half-life	20-80 hours (mean ~48 hours)
Active metabolite (desmethyldiazepam)	Half-life 50-120 hours

Dosage and Administration

Usual Adult Doses (Educational Reference):

• Anxiety (Moderate symptoms): 2-5 mg, 2-4 times daily
• Anxiety (Severe symptoms): 5-10 mg, 3-4 times daily
• Alcohol Withdrawal: 10 mg, 3-4 times during first 24 hours, tapered thereafter
• Muscle Spasm: 2-10 mg, 3-4 times daily

Prescribing Notes:

• Treatment should be as short as possible (usually 2-4 weeks for anxiety, up to 4 weeks for insomnia). Longer-term use requires specialist evaluation.
• Abrupt discontinuation should be avoided. Taper dosage gradually under medical supervision.

Contraindications

• Known hypersensitivity to diazepam or other benzodiazepines
• Myasthenia gravis
• Severe respiratory insufficiency (e.g., COPD exacerbation, sleep apnea)
• Severe hepatic impairment
• Narrow-angle glaucoma (acute angle-closure glaucoma; open-angle glaucoma may be treated with concurrent therapy)

Warnings and Precautions

• Dependence and Withdrawal: Physical dependence can occur with prolonged use. Abrupt discontinuation or rapid dose reduction can cause acute withdrawal reactions, including seizures and death.
• Abuse and Addiction: Careful risk assessment is required before prescribing. Monitor for signs of diversion or misuse.
• Neonatal Sedation and Withdrawal: Use during pregnancy, especially in the third trimester, can cause neonatal sedation (floppy baby syndrome) and withdrawal symptoms lasting weeks.

Adverse Reactions (Side Effects)

Most Common (≥1%):

• Drowsiness, fatigue, sedation (“hangover” effect next day)
• Muscle weakness, ataxia (impaired coordination)
• Slurred speech (dysarthria)
• Dizziness, lightheadedness
• Blurred vision

Serious Adverse Reactions (Rare):

• Respiratory Depression: Particularly when co-administered with opioids or alcohol
• Anterograde Amnesia: Impaired formation of new memories
• Paradoxical Reactions: Agitation, aggression, hostility, rage, hallucinations — more common in children and elderly
• Blood dyscrasias and jaundice

Drug Interactions

Drug Class	Interaction Effect
Opioids (oxycodone, morphine, codeine)	Profound sedation, respiratory depression, coma, death
Alcohol	Additive CNS depression, increased risk of overdose and death
Other CNS Depressants (antihistamines, muscle relaxants, sedatives)	Additive sedative effects, increased dizziness and ataxia
Antidepressants (SSRIs)	Additive CNS depression
CYP3A4 Inhibitors (ketoconazole, erythromycin, grapefruit juice)	Increased diazepam levels, prolonged sedation

Tolerance, Dependence & Withdrawal

Tolerance: Reduced response to the same dose over time, requiring dose escalation for same effect.

Physical Dependence: The body adapts to the presence of the drug. Withdrawal symptoms may occur within 24-72 hours of last dose.

Withdrawal Symptoms (can be life-threatening):

• Rebound anxiety and panic attacks (worse than before treatment)
• Insomnia, vivid nightmares
• Irritability, agitation, confusion
• Tremors, sweating, tachycardia
• Seizures (grand mal)
• Psychosis (hallucinations, paranoia)

Overdose Signs and Treatment

Overdose Signs:

• Severe drowsiness, confusion, slurred speech
• Impaired coordination (ataxia)
• Hypotension (low blood pressure)
• Respiratory depression (slow or shallow breathing)
• Coma

Overdose Treatment (Emergency):

• Flumazenil: Benzodiazepine antagonist — use with caution due to risk of seizures, especially in chronic benzodiazepine users or those with co-ingestion of pro-convulsant drugs (e.g., TCAs)
• Activated charcoal: If patient presents within 1-2 hours of ingestion and has intact airway
• Supportive care: Airway management, IV fluids, monitoring

Note: Overdose with benzodiazepines alone rarely causes death, but combined with alcohol or opioids is frequently fatal.

Use in Specific Populations

Population	Consideration
Pregnancy	Category D. May cause fetal harm. Third-trimester use → neonatal sedation and withdrawal (hypotonia, apnea, feeding difficulties) [citation:3].
Breastfeeding	Diazepam is excreted in breast milk. Monitor infants for sedation, poor feeding, and poor weight gain.
Geriatric (≥65 years)	Increased sensitivity. Long half-life increases fall risk, hip fractures, and cognitive impairment. Lower starting doses (2-2.5 mg daily) [citation:7].
Hepatic Impairment	Significant dose reduction required. Metabolized primarily by the liver. Avoid in severe impairment.

Storage and Disposal

• Storage: Store at room temperature (59-86°F / 15-30°C) in a secure, locked cabinet out of reach of children and visitors. Protect from light and moisture.
• Disposal: Use a drug take-back program or DEA-authorized collection site. If no take-back program is available, flush down the toilet (FDA recommendation for benzodiazepines when take-back is not available due to high risk of diversion and toxicity in children).

Legal Status (United States)

Diazepam is a Schedule IV (C-IV) controlled substance under the Controlled Substances Act [citation:3]. Key restrictions:

• Prescription required — refills permitted up to 5 times within 6 months
• DEA registration required for prescribing and dispensing (no mid-level restrictions beyond standard DEA)
• Illegal to possess without a valid prescription
• Penalties for illegal possession: up to 1 year imprisonment + fines (first offense)

Counterfeit Identification Guide (Educational)

The following signs are common in counterfeit “Actavis” or generic blue 10mg diazepam tablets [citation:1]:

Characteristic	Genuine (if available)	Common Counterfeit
Imprint	“C | DC”, “D 10”, “3927 / TEVA”, “ROCHE”, “Z 3927 10”	Often replicas of “C DC” or “D 10” but blurry/incorrect font
Packaging	Child-resistant, rigid blister packs, clear printing [citation:1]	Flimsy blister packs, Actavis labeling but Actavis no longer manufacturers
Active Ingredients	Diazepam (10mg)	Etizolam, Flubromazolam, Bromazolam, or other research chemicals [citation:1]
Effect perception	Sedation, muscle relaxation, anxiolysis within 30-60 minutes	No effect (inactive) or overly strong/amnesic effects [citation:1]

Educational Summary

Diazepam 10mg tablets are Schedule IV benzodiazepines indicated for anxiety, alcohol withdrawal, muscle spasms, and seizure disorders. Common FDA-approved imprints include “D 10”, “3927 / TEVA”, “Z 3927 10”, and “ROCHE / ROCHE / VALIUM 10”. The UK brand “Actavis” (imprint C|DC) has been discontinued for years; any tablets found with this imprint are almost certainly counterfeit and often contain undeclared research chemicals. Diazepam carries risks of dependence, withdrawal seizures, and fatal respiratory depression when combined with opioids or alcohol. Abrupt withdrawal can be life-threatening. Medical supervision for tapering is essential.

Note: This information is for educational and pharmacy reference purposes only. Diazepam is a Schedule IV controlled substance available by prescription only. This content does not constitute medical advice. If you or someone you know is experiencing an overdose, call 911 immediately. If you need help for substance use, contact SAMHSA at 1-800-662-4357.

Quantity	50, 100, 250, 500, 1000